Author's response to reviews Title: A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines Authors:
نویسندگان
چکیده
Christian Freise ([email protected]) Martin Ruehl ([email protected]) Ulrike Erben ([email protected]) Ulf Neumann ([email protected]) Daniel Seehofer ([email protected]) Ki Young Kim ([email protected]) Wolfram Trowitzsch-Kienast ([email protected]) Thorsten Stroh ([email protected]) Martin Zeitz ([email protected]) Rajan Somasundaram ([email protected])
منابع مشابه
A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines
BACKGROUND In traditional Chinese and Korean medicine, an aqueous extract derived from wood and bark of the Japanese spice bush Lindera obtusiloba (L.obtusiloba) is applied to treat inflammations and chronic liver diseases including hepatocellular carcinoma. We previously demonstrated anti-fibrotic effects of L.obtusiloba extract in hepatic stellate cells. Thus, we here consequently examine ant...
متن کاملbrotic (+)-Episesamin Isolated from Lindera obtusiloba BLUME
In traditional Korean medicine, an aqueous extract of the plant Lindera obtusiloba has been used for centuries to treat infl ammation, improve blood circulation, and prevent liver damage (Yook, 1989). Recently, we demonstrated antifi brotic, antioxidative, anti-infl ammatory, and antiadipogenic activity of this extract (Rühl et al., 2009; Freise et al., 2009). Freise et al. (2011) documented th...
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The insulin-like growth factor I receptor (IGF-IR) plays an essential role in the establishment and maintenance of transformed phenotype. Interference with the IGF-IR pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. We stably transfected the PC-3 human prostate cancer cell line with an IGF-IR antisense RNA expression plasmid. The ...
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Introduction Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective: We hypothesi...
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تاریخ انتشار 2011